Journal article
Clinical predictors of immune reconstitution following combination antiretroviral therapy in patients from the australian HIV observational database
R Rajasuriar, M Gouillou, T Spelman, T Read, J Hoy, M Law, PU Cameron, K Petoumenos, SR Lewin
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Background: A small but significant number of patients do not achieve CD4 T-cell counts >500cells/μl despite years of suppressive cART. These patients remain at risk of AIDS and non-AIDS defining illnesses. The aim of this study was to identify clinical factors associated with CD4 T-cell recovery following long-term cART. Methods: Patients with the following inclusion criteria were selected from the Australian HIV Observational Database (AHOD): cART as their first regimen initiated at CD4 T-cell count <500cells/μl, HIV RNA500cells/μl and >200cells/μl. Results: 501 patients were eligible for inclusion from AHOD (n = 2853). The median (IQR) age and baseline CD4 T-cell counts were 39 (32-47) ye..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The Australian HIV Observational Database is funded as part of the Asia Pacific HIV Observational Database, a program of The Foundation for AIDS Research, amfAR, and is supported in part by a grant from the U. S. National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) (Grant No. U01-AI069907) and by unconditional grants from Merck Sharp & Dohme; Gilead; Bristol-Myers Squibb; Boehringer Ingelheim; Roche; Pfizer; GlaxoSmithKline; and Janssen-Cilag. The National Centre in HIV Epidemiology and Clinical Research is funded by The Australian Government Department of Health and Ageing, and is affiliated with the Faculty of Medicine, The University of New South Wales. RR is a recipient of the King Scholarship from the Malaysian government. SRL is an NHMRC Practitioner Fellow. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.